4-Methoxy-o-phenylenediamine → HCID 178488051, compound

HRID 1108599Notes

Reaction equation

HRID 1108599 reaction equation
Cl.[CH3:2][O:3][C:4]1[C:13]2[N:12]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:10]=[CH:9][C:8]=2[C:7]([C:18](Cl)=O)=[CH:6][CH:5]=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[C:25]([NH2:30])[CH:24]=1>>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:18]2[NH:29][C:26]3[CH:27]=[CH:28][C:23]([O:22][CH3:21])=[CH:24][C:25]=3[N:30]=2)=[C:8]2[C:13]=1[N:12]=[C:11]([C:14]([F:15])([F:16])[F:17])[CH:10]=[CH:9]2

Participants

3

Reactant 2

HCID 1534044-Methoxy-o-phenylenediamineHCID 131721827HCID 131721827, compound2×

Product 1

HCID 178488051HCID 178488051, compound

Procedure

Prepared from 8-methoxy-2-trifluoromethylquinoline-5-carbonyl choride, hydrochloride (Intermediate 35 of PCT/GB97/01359) and 4-methoxy-1,2-phenylenediamine; purification by column chromatography eluting with 50%-70% ethyl acetate in hexane afforded the title compound as a pale yellow solid (1.32 g).

Workup

  1. custompurification by column chromatography
  2. washeluting with 50%-70% ethyl acetate in hexane

Sources & evidence

ORD record
ord-796c3244dd82459ba9c73d2e4292426a
Source dataset
uspto-grants-2000_05
Patent number
US06069151

Reaction notes

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