Sodium Hydroxide → HCID 178488853, compound

HRID 1108600Notes

Reaction equation

HRID 1108600 reaction equation
[OH-].[Na+].[F:3][C:4]([F:31])([F:30])[C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[C:8]([O:28][CH3:29])[CH:9]=[CH:10][C:11]=2[C:15]2[NH:19][C:18]3[CH:20]=[CH:21][C:22]([C:24]([O:26]C)=[O:25])=[CH:23][C:17]=3[N:16]=2)[N:6]=1>C(O)C>[CH3:29][O:28][C:8]1[CH:9]=[CH:10][C:11]([C:15]2[NH:19][C:18]3[CH:20]=[CH:21][C:22]([C:24]([OH:26])=[O:25])=[CH:23][C:17]=3[N:16]=2)=[C:12]2[C:7]=1[N:6]=[C:5]([C:4]([F:30])([F:31])[F:3])[CH:14]=[CH:13]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178497344HCID 178497344, compound

Product 1

HCID 178488853HCID 178488853, compoundYield 91.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium hydroxide (1M, 40 ml) was added to a stirred suspension of 2-(2-trifluoromethyl-8-methoxyquinolin-5-yl)-1H-benzimidazole-5-carboxylic acid, methyl ester (1 g) in ethanol (40 ml) at room temperature. The reaction was heated to 80° C. for 4h and cooled to room temperature. The ethanol was removed in vacuo and the remaining aqueous phase acidified to pH 5 with glacial acetic acid. The resulting solid was collected by filtration and dried in vacuo to give the titled compound as a brown solid (0.88 g).

Workup

  1. customThe ethanol was removed in vacuo
  2. filtrationThe resulting solid was collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-c16e4472084e4e0587fd8f9093fed5ae
Source dataset
uspto-grants-2000_05
Patent number
US06069151

Reaction notes

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