1,1'-Carbonyldiimidazole → HCID 70104510, compound

HRID 1108606Notes

Reaction equation

HRID 1108606 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=O)=[N:2]1.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:25][CH:26]1[C@H:32]2[N:33]([CH3:34])[C@H:29]([CH2:30][CH2:31]2)[CH2:28][CH2:27]1>>[C@@H:29]12[N:33]([CH3:34])[C@@H:32]([CH2:31][CH2:30]1)[CH:26]([NH:25][C:10]([C:3]1[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][N:2]=1)=[O:12])[CH2:27][CH2:28]2

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 78250Indazole-3-carboxylic acidHCID 55285637HCID 55285637, compound

Product 1

HCID 70104510HCID 70104510, compoundYield 18%

Procedure

1H-Indazole-3-carboxylic acid (9.73 g, 60 mmol), 1,1'-carbonyldiimidazole (9.74 g, 60 mmol), and 4-aminotropane (8.42 g, 60 mmol) were converted to the title compound by the procedure of Preparation 7, Step 2 to give 3.02 g. Yield: 18%. m.p. 222° C.-224° C. EA calculated for C16H20N4O: C, 67.58; H, 7.09; N, 19.70. Found: C, 67.65; H, 7.25; N, 19.75. MS(FD) M+284.

Sources & evidence

ORD record
ord-af8ae1c9d9f2452893b4f573790dd21c
Source dataset
uspto-grants-2000_05
Patent number
US06069152

Reaction notes

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