HCID 18783934, compound → 2-(Dimethylamino)ethyl alpha-hydroxy-alpha-phenylbenzeneacetate
Reaction equation
CN(C)CC[C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([OH:11])[C:8]([OH:10])=[O:9].[CH3:23][N:24]([CH3:45])[CH2:25][CH2:26]C1C=CC=CC=1C(C1C=CC=CC=1)(O)C(OC)=O>>[CH3:23][N:24]([CH3:45])[CH2:25][CH2:26][O:10][C:8](=[O:9])[C:7]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([C:6]1[CH:5]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:11]Participants
3
Procedure
0.24 g (0.802 mmol) of o-(2-dimethylaminoethyl)benzilic acid shown below was obtained as a faint yellow solid from 0.31 g (1.0 mmol) of methyl o-(2-dimethylaminoethyl)benzilate in the same manner as in Production Example 2 (4). ##STR24## Its spectroscopic data are as follows: 1H-NMR (CDCl3) δ (ppm) : 2.87 (6H, s), 3.09 (2H, t, J=4.8 Hz), 3.51 (2H, t, J=4.8 Hz), 7.21~7.30 (6H, m), 7.50~7.54 (4H, m).
Sources & evidence
- ORD record
- ord-5b5014e8840f45aba6724bb3ba4489c2
- Source dataset
- uspto-grants-2000_05
- Patent number
- US06069149
Reaction notes
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