Trifluoroacetic acid → HCID 18783938, compound

HRID 1108652Notes

Reaction equation

HRID 1108652 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>C(Cl)Cl>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15314931HCID 15314931, compound

Product 1

HCID 18783938HCID 18783938, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.13 g (16.11 mmol) of N-[4-(tert-butoxycarbonylamino)butyl]phthalimide was dissolved in 100 ml of methylene chloride and 6.21 ml (80.56 mmol) of trifluoroacetic acid was added thereto. The mixture was stirred overnight at room temperature. The reaction mixture was concentrated to dryness, then dried by heating in vacuum at 50° C. to obtain 5.35 g (16.10 mmol) of N-(4-aminobutyl)phthalimide trifluoroacetate as a pale brown solid.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customdried
  3. temperatureby heating in vacuum at 50° C.

Sources & evidence

ORD record
ord-a2f95dcdccc44ec08fde27b24513a99c
Source dataset
uspto-grants-2000_05
Patent number
US06069149

Reaction notes

Loading…