Isobutyryl chloride → Methyl 2-isobutyl-3-isobutyrylindole-6-carboxylate

HRID 1108682Notes

Reaction equation

[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([C:14]([O:16][CH3:17])=[O:15])[CH:8]=2)[CH:2]([CH3:4])[CH3:3].[C:18](Cl)(=[O:22])[CH:19]([CH3:21])[CH3:20]>>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13]=1[C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])=[CH:11][CH:10]=[C:9]([C:14]([O:16][CH3:17])=[O:15])[CH:8]=2)[CH:2]([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 22627278Methyl 2-isobutylindole-6-carboxylate

Product 1

HCID 22627171Methyl 2-isobutyl-3-isobutyrylindole-6-carboxylate

Procedure

Methyl 2-isobutyl-3-isobutyrylindole-6-carboxylate (246 mg) was prepared from methyl 2-isobutylindole-6-carboxylate (300 mg) and isobutyryl chloride (0.41 ml) in a similar manner to that of Preparation 1 (5).

Sources & evidence

ORD record: ord-f67d5fea00ef4bef95f37f3368d878b7
Source dataset: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06069156

Reaction notes

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