反应详情

To a solution of methyl 2-acetamido-3-acetoxybenzoate (1.72 g) in methanol (9 ml) was added powdered potassium carbonate (1.4 g), and the mixture was stirred for 20 minutes. The resulting solid was removed by filtration and washed with methanol. The filtrate was evaporated in vacuo, and the residue was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was triturated with a mixture of isopropyl ether and hexane to give methyl 2-acetamido-3-hydroxybenzoate (1.21 g) as solid.

1. customThe resulting solid was removed by filtration
2. washwashed with methanol
3. customThe filtrate was evaporated in vacuo
4. extractionextracted with ethyl acetate
5. washThe organic phase was washed with brine
6. dry with materialdried over sodium sulfate
7. customevaporated in vacuo
8. customThe residue was triturated with a mixture of isopropyl ether and hexane