Thioacetamide → HCID 9823301, compound

HRID 1108827Notes

Reaction equation

HRID 1108827 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21](=O)[CH2:22]Br.[C:25]([NH2:28])(=[S:27])[CH3:26]>C(O)C>[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21]1[N:28]=[C:25]([CH3:26])[S:27][CH:22]=1

Participants

4

Reactant 2

HCID 2723949ThioacetamideHCID 22120909HCID 22120909, compound

Product 1

HCID 9823301HCID 9823301, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 5-amino-4-bromoacetyl-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.1 g) in ethanol (5 ml) was added thioacetamide (0.0375 g). After 1 hour at room temperature the mixture was evaporated and the residue was purified by column chromatography on silica gel (10 g) eluted with dichloromethane. Combination and evaporation of suitable fractions gave the title compound as a white solid, m.p. 226-8° C.

Workup

  1. customAfter 1 hour at room temperature the mixture was evaporated
  2. customthe residue was purified by column chromatography on silica gel (10 g)
  3. washeluted with dichloromethane
  4. customCombination and evaporation of suitable fractions

Sources & evidence

ORD record
ord-398def7474164838a92a1f6f0181d059
Source dataset
uspto-grants-2000_05
Patent number
US06069157

Reaction notes

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