L-Aspartic Acid → HCID 25168487, compound

HRID 1108918Notes

Reaction equation

HRID 1108918 reaction equation
[OH-:1].[Na+:2].[NH2:3][C@H:4]([C:9]([OH:11])=[O:10])[CH2:5][C:6]([OH:8])=[O:7]>O>[Na+:2].[Na+:2].[Na+:2].[Na+:2].[OH:1][CH:4]([C:9]([O-:11])=[O:10])[CH:5]([NH:3][CH:4]([CH2:5][C:6]([O-:8])=[O:7])[C:9]([O-:11])=[O:10])[C:6]([O-:8])=[O:7]

Participants

4

Reactant 2

HCID 5960L-Aspartic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 25168487HCID 25168487, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.0 g (0.2 mol) sodium hydroxide and then 17.6 g (0.1 mol) cis-epoxysuccinic acid disodium salt were added with stirring at room temperature to 13.3 g (0.1 mol) L-aspartic acid in 50 ml water. The clear, pale yellow solution was heated under reflux for 8 hours. The solvent was then removed in a rotary evaporator (vacuum). 3-Hydroxy-2,2'-iminodisuccinic acid tetrasodium salt (B1) in the form of a C(3) epimer mixture was obtained in a yield of 36.8 g. According to 1H-NMR, the colorless solid contained approx. 5% by weight disodium tartrate (signal at=4.40).

Workup

  1. temperatureThe clear, pale yellow solution was heated
  2. temperatureunder reflux for 8 hours
  3. customThe solvent was then removed in a rotary evaporator (vacuum)

Sources & evidence

ORD record
ord-59ddf87f9d854ae1bafe288a026fa47c
Source dataset
uspto-grants-1994_06
Patent number
US05318726

Reaction notes

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