Pyridine → 2-(4-Decyloxybenzoylamino)-4-octylphenol

HRID 1108922ノート

反応式

HRID 1108922 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]=[CH:4][C:3]=1[OH:16].[CH2:17]([O:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].O1CCOCC1.N1C=CC=CC=1>O>[CH2:17]([O:27][C:28]1[CH:29]=[CH:30][C:31]([C:32]([NH:1][C:2]2[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]=[CH:4][C:3]=2[OH:16])=[O:33])=[CH:35][CH:36]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

参加物

6

反応物 4

HCID 1049PyridineHCID 312751,4-DioxaneHCID 87767Phenol, 2-amino-4-octyl-HCID 117793534-Decyloxybenzoyl chloride

生成物 1

HCID 190211542-(4-Decyloxybenzoylamino)-4-octylphenol収率 97.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 50 ml-three-necked flask, 0.50 g (2.43 mM) of 2-amino-4-octylphenol, 0.82 g (2.54 mM) of 4-decyloxybenzoyl chloride and 20 ml of dioxane were placed and heated. To the mixture, 0.88 ml of pyridine was gradually added dropwise at around 90° C. under stirring, followed by further stirring for 35 minutes at around 90° C. After the reaction, the reaction mixture was poured into water to precipitate a crystal. The crystal was recovered by filtration and washed with water, followed by recrystallization from hydrous acetone to obtain 1.06 g of 2-(4-decyloxybenzoylamino)-4-octylphenol (yield: 90.4%).

後処理

  1. temperatureheated
  2. stirringby further stirring for 35 minutes at around 90° C
  3. customAfter the reaction
  4. customto precipitate a crystal
  5. filtrationThe crystal was recovered by filtration
  6. washwashed with water
  7. customfollowed by recrystallization from hydrous acetone

出典と根拠

ORDレコード
ord-0d3bac9c0abb4c559257239174c483bd
出典データセット
uspto-grants-1994_06
特許番号
US05318720

反応ノート

読み込み中…