HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxacyclohexadecane-2,13-dione → 13-Hydroxy-oxacyclohexadecan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxacyclohexadecane-2,13-dione | HCID 3094320 | — |
| Catalyst | Cobalt | HCID 104730 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 13-Hydroxy-oxacyclohexadecan-2-one | HCID 3094319 | 95.2% |
Reaction Steps
480 g (1.89 mol) of 12-oxo-15-pentadecanolide (VI) are mixed with 1,000 g of isopropanol and hydrogenated in an autoclave with addition of 9.6 g of Raney cobalt under a hydrogen pressure of 100 bar at 135° C. After the solvent has been stripped off, distillation of the residue gives 460 g (1.80 mol) of 12-hydroxy-15-pentadecanolide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05319104 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-fcba679ea5e94575a5593701b871ce4f |
| Source note | uspto-grants-1994_06 |