反应详情

480 g (1.89 mol) of 12-oxo-15-pentadecanolide (VI) are mixed with 1,000 g of isopropanol and hydrogenated in an autoclave with addition of 9.6 g of Raney cobalt under a hydrogen pressure of 100 bar at 135° C. After the solvent has been stripped off, distillation of the residue gives 460 g (1.80 mol) of 12-hydroxy-15-pentadecanolide.

1. distillationdistillation of the residue