反应详情

473 g (4.64 mol) of acetic anhydride are initially introduced into a flask and heated to 135°-140° C. (reflux). 982 g (3.83 mol) of 12-hydroxy-15-pentadecanolide (VII) are added dropwise. The mixture is allowed to after-react under reflux for a further hour. The excess acetic acid/acetic anhydride is then distilled off under a weak vacuum. 1120 g of 12-acetoxy-15-pentadecanolide are obtained;

1. temperatureheated to 135°-140° C.
2. temperature(reflux)
3. customto after-react
4. temperatureunder reflux for a further hour
5. distillationThe excess acetic acid/acetic anhydride is then distilled off under a weak vacuum