HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 12-Acetoxy-15-pentadecanolide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 13-Hydroxy-oxacyclohexadecan-2-one | HCID 3094319 | — |
| Product | 12-Acetoxy-15-pentadecanolide | HCID 15041692 | 98% |
Reaction Steps
473 g (4.64 mol) of acetic anhydride are initially introduced into a flask and heated to 135°-140° C. (reflux). 982 g (3.83 mol) of 12-hydroxy-15-pentadecanolide (VII) are added dropwise. The mixture is allowed to after-react under reflux for a further hour. The excess acetic acid/acetic anhydride is then distilled off under a weak vacuum. 1120 g of 12-acetoxy-15-pentadecanolide are obtained;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05319104 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-b18b715a3d934fccbad4aa37a47d74b1 |
| Source note | uspto-grants-1994_06 |