反应详情

A stirred suspension of 2-ethyl valeramide (33.0 g, 286 mmol) in 220 ml of ethyl acetate was cooled to 0° and hypochlorous acid (55.25 g of 27.67% solution, 291 mmol) was added over 15 minutes. The cooling bath was removed and stirring continued for 1/2 hour. The organic phase was collected and dried (MgSO4) and the solvent was removed on a rotary evaporator to yield 32.8 g of N-chloro-2-methyl valeramide as a clear yellow liquid.

1. temperaturewas cooled to 0°
2. customThe cooling bath was removed
3. customThe organic phase was collected
4. dry with materialdried (MgSO4)
5. customthe solvent was removed on a rotary evaporator