反应详情

温度

50 °C

To thionyl chloride (93 g, 782 mmol), cooled to 15° C. in a water bath was added during 1 hour 2-methyl decanoic acid (64 g, 344 mmol). The cold water bath was removed and the mixture was heated at 50° C. with stirring for 45 minutes. The excess thionyl chloride was removed by distillation and the crude acid chloride was then fractionally distilled (b.p. 143°-45° C./5.8 mm) to give 69 g of product (99% yield) that showed an assay of >98% by GC.

1. customThe cold water bath was removed
2. customThe excess thionyl chloride was removed by distillation
3. distillationthe crude acid chloride was then fractionally distilled (b.p. 143°-45° C./5.8 mm)