Hydrochloric Acid → HCID 178429711, compound

HRID 1109328Notes

Reaction equation

HRID 1109328 reaction equation
[SH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13]CC)=[O:12])=[C:6]2[N:5]=[C:4]([CH3:16])[CH:3]=1.Cl>[OH-].[Na+]>[SH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[C:6]2[N:5]=[C:4]([CH3:16])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178469974HCID 178469974, compound

Product 1

HCID 178429711HCID 178429711, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 7-mercapto-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (J. Med. Chem. 1981, 24(5), 610-13) was heated in 1N aqueous sodium hydroxide solution until all has passed into solution. The reaction mixture was cooled and its pH was adjusted to 1 with aqueous hydrochloric acid. The resulting precipitate was filtered off, dried and recrystallized from dimethylformamide. There was obtained 7-mercapto-5-methyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid as a yellow powder having a of melting point of 161-162° (dec.).

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationThe resulting precipitate was filtered off
  3. customdried
  4. customrecrystallized from dimethylformamide

Sources & evidence

ORD record
ord-a6a025c5c1ec4b44b287b03799c21021
Source dataset
uspto-grants-1994_06
Patent number
US05319140

Reaction notes

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