Sodium Hydroxide → HCID 3720124, compound

HRID 1109447Notes

Reaction equation

HRID 1109447 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14]([CH3:15])=[C:13]([C:16]([O:18]CC)=[O:17])[CH:12]=[N:11]1.[OH-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14]([CH3:15])=[C:13]([C:16]([OH:18])=[O:17])[CH:12]=[N:11]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 2805560HCID 2805560, compound

Product 1

HCID 3720124HCID 3720124, compoundYield 71.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

By the method of Example 1, Step D, 40.0 g (0.12 mole) of 1-(2,4,6-trichlorophenyl)-4-ethoxycarbonyl-5-methyl-1H-pyrazole and 5.75 g (0.14 mole) of sodium hydroxide were reacted in 40 mL of ethanol and 30 mL of water, yielding 26.2 g of 1-(2,4,6-trichlorophenyl)-4-carboxy-5-methyl-1H-pyrazole as a light tan solid; mp 184°-186.5° C. The NMR spectrum was consistent with the proposed structure.

Sources & evidence

ORD record
ord-55d17d42b67247cc900c642c6e91211f
Source dataset
uspto-grants-1994_06
Patent number
US05321002

Reaction notes

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