HCID 14127504, compound → HCID 10427052, compound

HRID 1109455Notes

Reaction equation

HRID 1109455 reaction equation
C([O:3][C:4](=[O:25])[CH:5]([NH2:24])[CH2:6][C:7]1[CH:8]=[C:9]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:10]=[C:11]([CH2:13][P:14]([OH:17])([OH:16])=[O:15])[CH:12]=1)C>Cl>[NH2:24][CH:5]([CH2:6][C:7]1[CH:8]=[C:9]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:10]=[C:11]([CH2:13][P:14]([OH:17])([OH:16])=[O:15])[CH:12]=1)[C:4]([OH:25])=[O:3]

Participants

3

Reactant 1

HCID 14127504HCID 14127504, compound

Product 1

HCID 10427052HCID 10427052, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent3×

Procedure

The compound of Example 15 and 1N hydrochloric acid are heated at 60° for 2 hours. After evaporating to dryness the residue is dissolved in tetrahydrofuran/water and treated with propylene oxide, whereby the title compound is obtained, m.p. 275°-278° (decomp.). [α]D20 =0.0±0.5° (c=1 in 6N HCl), [α]36520 =+21.3° (c=1 in 6N HCl).

Workup

  1. customAfter evaporating to dryness the residue
  2. dissolutionis dissolved in tetrahydrofuran/water
  3. additiontreated with propylene oxide, whereby the title compound
  4. customis obtained

Sources & evidence

ORD record
ord-2b3b2a7466f642019f298b856e4cec8e
Source dataset
uspto-grants-1994_06
Patent number
US05321016

Reaction notes

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