Methyl iodide → HCID 19020589, compound

HRID 1109476Notes

Reaction equation

[Cl:1][C:2]1[CH:24]=[C:23]([NH:25][C:26](=[O:29])[CH2:27][CH3:28])[CH:22]=[CH:21][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:8][CH2:7]1)=[O:5].[CH3:30]I>>[CH3:30][N:25]([C:23]1[CH:22]=[CH:21][C:3]([C:4]([N:6]2[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)[CH2:10][CH2:11]2)=[O:5])=[C:2]([Cl:1])[CH:24]=1)[C:26](=[O:29])[CH2:27][CH3:28]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19020575HCID 19020575, compound

Product 1

HCID 19020589HCID 19020589, compound

Procedure

In a manner analogous to that described in Example 5, 0.8 g of 1-[2-chloro-4-(N-propionylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine is methylated with 0.29 g of methyl iodide to form 1-[4-(N-methyl-N-propionylamino)-2-chlorobenzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine and converted into the hydrochloride having a melting point of 135°.

Sources & evidence

ORD record: ord-6324ee30b1974fb58e07b004a93ae4bb
Source dataset: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05321027

Reaction notes

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