Methyl iodide → HCID 19020589, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 5, 0.8 g of 1-[2-chloro-4-(N-propionylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine is methylated with 0.29 g of methyl iodide to form 1-[4-(N-methyl-N-propionylamino)-2-chlorobenzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine and converted into the hydrochloride having a melting point of 135°.

Provenance & Evidence