HCID 19020584, compound → HCID 19020581, compound

HRID 1109479Notes

Reaction equation

HRID 1109479 reaction equation
Cl.[Cl:2][C:3]1[CH:25]=[C:24]([N:26](C(OCC2C=CC=CC=2)=O)[CH3:27])[CH:23]=[CH:22][C:4]=1[C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:9][CH2:8]1)=[O:6]>CO.[Pd]>[CH3:27][NH:26][C:24]1[CH:23]=[CH:22][C:4]([C:5]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[CH2:9][CH2:8]2)=[O:6])=[C:3]([Cl:2])[CH:25]=1

Participants

4

Reactant 1

HCID 19020584HCID 19020584, compound

Product 1

HCID 19020581HCID 19020581, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The 1-[2-chloro-4-(N-benzyloxycarbonyl-N-methylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine hydrochloride obtained in accordance with Example 18 is dissolved in 15 ml of methanol and debenzylated in the presence of 0.2 g of 10% palladium-on-carbon, yielding 1-[4-(N-methylamino)-2-chlorobenzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine having a melting point of 200°.

Sources & evidence

ORD record
ord-a6f6ffeca8064889a94c48b23ff41e52
Source dataset
uspto-grants-1994_06
Patent number
US05321027

Reaction notes

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