Hydrochloric Acid → HCID 15630380, compound

Participants

Reaction Steps

2.00 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 2.50 g (7.4 mmoles) of 2-(2-hydroxy-3-morpholinopropyl)-4-methyl-5-phenyl-3-isoxazolone (prepared as described in Example 1) in 25 ml of ethanol, and the mixture was stirred at room temperature for 3 hours. At the end of this time, the crystals which deposited were collected by filtration, washed with 10 ml of isopropanol, and recrystallized from ethanol, to give 2.30 g (yield 87.7%) of the title compound as a colorless powder, melting at 130°-133° C.

Provenance & Evidence