Hydrochloric Acid → HCID 15630380, compound

HRID 1109512Notes

Reaction equation

HRID 1109512 reaction equation
[ClH:1].[OH:2][CH:3]([CH2:18][N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)[CH2:4][N:5]1[C:9](=[O:10])[C:8]([CH3:11])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:6]1>O1CCOCC1.C(O)C>[ClH:1].[OH:2][CH:3]([CH2:18][N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)[CH2:4][N:5]1[C:9](=[O:10])[C:8]([CH3:11])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15630379HCID 15630379, compound

Product 1

HCID 15630380HCID 15630380, compoundYield 87.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2.00 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 2.50 g (7.4 mmoles) of 2-(2-hydroxy-3-morpholinopropyl)-4-methyl-5-phenyl-3-isoxazolone (prepared as described in Example 1) in 25 ml of ethanol, and the mixture was stirred at room temperature for 3 hours. At the end of this time, the crystals which deposited were collected by filtration, washed with 10 ml of isopropanol, and recrystallized from ethanol, to give 2.30 g (yield 87.7%) of the title compound as a colorless powder, melting at 130°-133° C.

Workup

  1. filtrationAt the end of this time, the crystals which deposited were collected by filtration
  2. washwashed with 10 ml of isopropanol
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-709b4364a9e445559ff962b777351e78
Source dataset
uspto-grants-1994_06
Patent number
US05321037

Reaction notes

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