Hydrochloric Acid → HCID 19020719, compound

HRID 1109518Notes

Reaction equation

HRID 1109518 reaction equation
[ClH:1].[OH:2][CH:3]([CH2:18][N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)[CH2:4][O:5][C:6]1[C:10]([CH3:11])=[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:8][N:7]=1>O1CCOCC1.C(O)C>[ClH:1].[OH:2][CH:3]([CH2:18][N:19]1[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1)[CH2:4][O:5][C:6]1[C:10]([CH3:11])=[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:8][N:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 14652026HCID 14652026, compound

Product 1

HCID 19020719HCID 19020719, compoundYield 90.4%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2.75 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 3.18 g of 3-(2-hydroxy-3-morpholinopropoxy)-4-methyl-5-phenylisozazole (prepared as described in Example 5) in 50 ml of ethanol, and the mixture was stirred at room temperature for 3 hours. At the end of this time, the crystalline substance which deposited was recrystallized from ethanol, to give 3.20 g (yield 90.4%) of the title compound as colorless granules, melting at 189°-191° C. (with decomposition).

Workup

  1. customAt the end of this time, the crystalline substance which deposited was recrystallized from ethanol

Sources & evidence

ORD record
ord-d80a19ef72ff4808b89b3e32ffc48ddf
Source dataset
uspto-grants-1994_06
Patent number
US05321037

Reaction notes

Loading…