Hydrochloric Acid → HCID 15925335, compound

Participants

Reaction Steps

A 7.7 solution (0.59 cc) of hydrochloric acid in ethanol is added dropwise in the course of 5 minutes to a solution of N-benzyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (2.0 g), in absolute ethanol (30 cc). The solution is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) and the residue is suspended in ethyl ether (100 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give N-benzyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride, L series (1.91 g), in the form of a white solid, m.p. 218° C.

Provenance & Evidence