Hydrochloric Acid → HCID 15925335, compound

HRID 1109546Notes

Reaction equation

HRID 1109546 reaction equation
[ClH:1].[CH2:2]([NH:9][C:10]([C:12]1[CH:25]=[CH:24][C:23]2[S:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]([CH:26]([CH3:33])[CH2:27][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[C:14]=2[CH:13]=1)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[ClH:1].[CH2:2]([NH:9][C:10]([C:12]1[CH:25]=[CH:24][C:23]2[S:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]([CH:26]([CH3:33])[CH2:27][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[C:14]=2[CH:13]=1)=[O:11])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15096221N-benzyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide

Product 1

HCID 15925335HCID 15925335, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A 7.7 solution (0.59 cc) of hydrochloric acid in ethanol is added dropwise in the course of 5 minutes to a solution of N-benzyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (2.0 g), in absolute ethanol (30 cc). The solution is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) and the residue is suspended in ethyl ether (100 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give N-benzyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride, L series (1.91 g), in the form of a white solid, m.p. 218° C.

Workup

  1. concentrationThe solution is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa)
  2. customdried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C.

Sources & evidence

ORD record
ord-04f6c84f282d42dfa552f99cb9351fbc
Source dataset
uspto-grants-1994_06
Patent number
US05321026

Reaction notes

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