Diketene → N-(2,3-Dihydroxypropyl)-3-oxobutanamide

HRID 1109610Notes

Reaction equation

HRID 1109610 reaction equation
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH:9]([OH:12])[CH2:10][OH:11]>>[C:4]([NH:7][CH2:8][CH:9]([OH:12])[CH2:10][OH:11])(=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

Participants

3

Reactant 2

HCID 12661DiketeneHCID 735613-Amino-1,2-propanediol

Product 1

HCID 15292094N-(2,3-Dihydroxypropyl)-3-oxobutanamide

Procedure

Diketene is reacted at a temperature of about 25 to 35° C. with 1-amino-2,3-propane diol in an aqueous solution to produce 1-acetoacetamido-2,3-propane diol, as illustrated below: ##STR1##

Sources & evidence

ORD record
ord-df3ad138ec304b099a0e39f338050013
Source dataset
uspto-grants-1994_06
Patent number
US05321118

Reaction notes

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