反应详情

To a solution of 1-methyl-5-(2-fluorobenzoyl)-1,2,3,4-tetrahydroquinoxaline (11.99 g) and pyridine (4.04 g) in methylene chloride (200 ml) was dropwise added a solution of bromoacetyl bromide (5.09 ml) in methylene chloride (10 ml) under stirring at a temperature below 10° C. and the mixture was stirred for 3 hours at the same temperature. The reaction mixture was washed with water twice and dried. Removal of the solvent afforded viscous oil. The viscous oil was triturated with diisopropyl ether, collected by filtration, washed with diisopropyl ether and dried to give 1-methyl-4-bromoacetyl-5-(2-fluorobenzoyl)-1,2,3,4-tetrahydroquinoxaline (17.18 g).

1. stirringthe mixture was stirred for 3 hours at the same temperature
2. washThe reaction mixture was washed with water twice
3. customdried
4. customRemoval of the solvent
5. customafforded viscous oil
6. customThe viscous oil was triturated with diisopropyl ether
7. filtrationcollected by filtration
8. washwashed with diisopropyl ether
9. customdried