Potassium Carbonate → HCID 67691668, compound

HRID 1109731Notes

Reaction equation

HRID 1109731 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][CH:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][NH:9]2)[CH2:3]1.[Cl:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27](Cl)=[O:28])[CH:22]=[CH:23][C:24]=1[Cl:25].C(=O)([O-])[O-].[K+].[K+]>>[ClH:18].[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2([C:27](=[O:28])[CH2:26][C:21]3[CH:22]=[CH:23][C:24]([Cl:25])=[C:19]([Cl:18])[CH:20]=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][NH:9]2)[CH2:3]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 19439841HCID 19439841, compound

Product 1

HCID 67691668HCID 67691668, compound

Procedure

Prepared as Example n° 1 from 5.0 g (21.5 mmoles) of 1-(3-hydroxypyrrolidin-1-yl)methyl-1,2,3,4-tetrahydroisoquinoline--diast. mix.--, 5.2 g (23.6 mmoles) of 3,4-dichlorophenylacetyl chloride and 3.6 g (23.6 mmoles) of anhydrous potassium carbonate.

Workup

  1. additionmix

Sources & evidence

ORD record
ord-65b7b01da0ba40ff9433a0b349ab83ae
Source dataset
uspto-grants-1994_06
Patent number
US05322848

Reaction notes

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