Potassium Carbonate → HCID 131718511, compound

HRID 1109732Notes

Reaction equation

HRID 1109732 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][CH2:11][NH:10]2)[CH2:3]1.[Cl:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28](Cl)=[O:29])[CH:23]=[CH:24][C:25]=1[Cl:26].C(=O)([O-])[O-].[K+].[K+]>>[ClH:19].[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C@@:9]2([C:28](=[O:29])[CH2:27][C:22]3[CH:23]=[CH:24][C:25]([Cl:26])=[C:20]([Cl:19])[CH:21]=3)[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][CH2:11][NH:10]2)[CH2:3]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 23190319HCID 23190319, compound

Product 1

HCID 131718511HCID 131718511, compound

Procedure

Prepared as Example n° 1 from 4.83 g (19.6 mmoles) of 1-(3-hydroxypiperidin-1-yl)methyl-1,2,3,4-tetrahydroisoquinoline--diast. mix.--, 5.15 g (23.1 mmoles) of 3,4-dichlorophenylacetyl chloride and 3.2 g (23.1 mmoles) of anhydrous potassium carbonate.

Workup

  1. additionmix

Sources & evidence

ORD record
ord-468a807f0f7b4f269ddb5fef35bdf564
Source dataset
uspto-grants-1994_06
Patent number
US05322848

Reaction notes

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