1-Methylpiperazine → HCID 10476561, compound

HRID 1109815Notes

Reaction equation

HRID 1109815 reaction equation
[N+:1]([C:4]1[CH:21]=[CH:20][C:7]([CH2:8][O:9][C:10]([N:12]2[CH2:17][C@@H:16]3[CH2:18][C@H:13]2[C:14](=[O:19])[S:15]3)=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C(Cl)Cl>[N+:1]([C:4]1[CH:21]=[CH:20][C:7]([CH2:8][O:9][C:10]([N:12]2[CH2:17][C@@H:16]([SH:15])[CH2:18][C@H:13]2[C:14]([N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[O:19])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 9904687HCID 9904687, compound

Product 1

HCID 10476561HCID 10476561, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1S,4S)-5-p-nitrobenzyloxycarbonyl -2-thia-5-azabicyclo[2.2.1]heptan-3-one (308 mg) in methylene chloride (2.0 g) was added N-methylpiperazine (105 mg). The mixture was stirred for 7 hours at room temperatures. After the reaction was over, the solvent was distilled to give solid 1-[(2S,4S)-1-p-nitrobenzyloxycarbonyl-4-mercapto-2-pyrrolidinecarbonyl]-4-methylpiperazine.

Workup

  1. distillationwas distilled

Sources & evidence

ORD record
ord-10a9905022a54e65983fd0293bec9f86
Source dataset
uspto-grants-1994_06
Patent number
US05322952

Reaction notes

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