Sulfuric Acid → HCID 22075337, compound

HRID 1109838Notes

Reaction equation

HRID 1109838 reaction equation
C([NH:4][CH:5]([C:11](=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)C(OCC)=O)(=O)C.[S:19](=[O:23])(=[O:22])([OH:21])[OH:20]>O>[S:19]([OH:23])([OH:22])(=[O:21])=[O:20].[CH2:5]([NH2:4])[C:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:18]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 2272876966-30-9

Product 1

HCID 22075337HCID 22075337, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

24.9 g of ethyl 2-acetamido-3-oxo-3-phenylpropionate, 7.2 g of sulfuric acid (96%) and 50 ml of water are refluxed, with stirring, for 10 hours. The reaction mixture is filtered and the filtrate is concentrated on a rotary evaporator. The crystalline residue is made into a paste with 50 ml of isopropanol, the crystals are isolated by suction filtration, washed with petroleum ether (50°-70° C.) and dried.

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated on a rotary evaporator
  3. customthe crystals are isolated by suction filtration
  4. washwashed with petroleum ether (50°-70° C.)
  5. customdried

Sources & evidence

ORD record
ord-e73f61badaf140f5aaa528eaed27334f
Source dataset
uspto-grants-1994_06
Patent number
US05322964

Reaction notes

Loading…