HRID1109846

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：N#CCCCCN(OCc1ccccc1)C(=O)CCCCNOCc1ccccc1

HCID10341465

未命名化合物

结构：CC(C)(C)OC(=O)N(CCCCC(=O)N(CCCCC(=O)N(CCCCC#N)OCc1ccccc1)OCc1ccccc1)OCc1ccccc1

HCID10484991

未命名化合物

PRODUCTS

生成物

结构：N#CCCCCN(OCc1ccccc1)C(=O)CCCCN(OCc1ccccc1)C(=O)CCCCNOCc1ccccc1

HCID9986266

未命名化合物

收率 57.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Compound (7) (2.85 g, 3.99 mmol) in CH2Cl2 was treated with excess TFA following the procedure used for (5). Silica gel column chromatography, eluting with 3:2 EtOAc/hexane gave 1.4 g (57%) of (8) as an oil: NMR δ 1.43-1.83 (m, 12 H), 2.20-2.50 (m, 6 H), 2.90 (t, 2 H, J=6), 3.60 (t, 4 H, J=6), 4.63 (s, 2 H), 4.75 (s, 4 H), 7.28 (s, 5 H) , 7.33 (s, 10 H). Anal. (C36H46N4O5) C, H, N.

WORKUP

后处理

washSilica gel column chromatography, eluting with 3:2 EtOAc/hexane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2712884e6ca546b2973cd8fafce32d5b
来源数据集: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05322961
来源说明: uspto-grants-1994_06

反应 SMILES

C(OC([N:8]([O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)[CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:44])[N:14]([O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:35])[N:20]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:21][CH2:22][CH2:23][CH2:24][C:25]#[N:26])=O)(C)(C)C.C(O)(C(F)(F)F)=O.C(ON(C(=O)CCCCNOCC1C=CC=CC=1)CCCCC#N)C1C=CC=CC=1>C(Cl)Cl>[CH2:28]([O:27][N:20]([C:19](=[O:35])[CH2:18][CH2:17][CH2:16][CH2:15][N:14]([O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:13](=[O:44])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)[CH2:21][CH2:22][CH2:23][CH2:24][C:25]#[N:26])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1