化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 6,12,18-Tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 6,12-Bis(benzyloxy)-7-oxo-6,12-diazadodecanenitrile | HCID 10341465 | — |
| 反応物 | 18-(tert-Butoxycarbonyl)-6,12,18-tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile | HCID 10484991 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6,12,18-Tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile | HCID 9986266 | 57.1% |
反応手順
Compound (7) (2.85 g, 3.99 mmol) in CH2Cl2 was treated with excess TFA following the procedure used for (5). Silica gel column chromatography, eluting with 3:2 EtOAc/hexane gave 1.4 g (57%) of (8) as an oil: NMR δ 1.43-1.83 (m, 12 H), 2.20-2.50 (m, 6 H), 2.90 (t, 2 H, J=6), 3.60 (t, 4 H, J=6), 4.63 (s, 2 H), 4.75 (s, 4 H), 7.28 (s, 5 H) , 7.33 (s, 10 H). Anal. (C36H46N4O5) C, H, N.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05322961 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-2712884e6ca546b2973cd8fafce32d5b |
| 出典メモ | uspto-grants-1994_06 |