反应详情

A solution of dodecylmagnesium bromide (a 1M solution in tetrahydrofuran; 14.3 ml; 14.3 mmol) was added to a solution of 2-trimethylsilyl-3-furaldehyde (1.20 g, 7.1 mmol) in tetrahydrofuran (30 ml) at 0°. After all the aldehyde has reacted, as shown by tlc, the mixture was quenched with dilute hydrochloric acid and was extracted with ethyl ether. Evaporation of the dried (magnesium sulfate) extracts gave an oil, which was purified by a silica column using 5% ethyl ether/hexane to give the title furan.

1. customthe mixture was quenched with dilute hydrochloric acid
2. extractionwas extracted with ethyl ether
3. customEvaporation of the
4. dry with materialdried (magnesium sulfate)
5. customextracts gave an oil, which
6. customwas purified by a silica column