Hydroxyphenylacetic acid → Ethyl 4-hydroxyphenylacetate

HRID 1109938Notes

Reaction equation

HRID 1109938 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 127Hydroxyphenylacetic acidHCID 702EthanolHCID 1118Sulfuric Acid

Product 1

HCID 28310Ethyl 4-hydroxyphenylacetate

Procedure

4-Hydroxyphenylacetic acid (50.0 g) is dissolved in ethanol (400 ml) and thereto is added conc. sulfuric acid (0.5 ml). The mixture is refluxed with stirring, and ethanol is distilled off to give ethyl 4-hydroxyphenylacetate (60 g).

Workup

  1. temperatureThe mixture is refluxed
  2. distillationethanol is distilled off

Sources & evidence

ORD record
ord-2c79fccf57814094a11141f155438608
Source dataset
uspto-grants-1994_06
Patent number
US05324450

Reaction notes

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