反应详情

30.0 g of methyl 2-chloro-6-methylpyrimidine-4-carboxylate are added to a solution of 4.2 g of sodium in 100 ml of methanol. The mixture is heated under reflux for 2 h and concentrated under reduced pressure, and the residue is taken upon in dichloromethane/water. The organic phase is separated off and the aqueous solution is extracted a further five times using dichloromethane. The combined organic extracts are dried over sodium sulfate and the solvent is distilled off under reduced pressure. 25.5 g of methyl 2-methoxy-6-methylpyrimidine-4-carboxylate of melting point 101°-103° C. are obtained in this way.

1. temperatureThe mixture is heated
2. temperatureunder reflux for 2 h
3. concentrationconcentrated under reduced pressure
4. customThe organic phase is separated off
5. extractionthe aqueous solution is extracted a further five times
6. dry with materialThe combined organic extracts are dried over sodium sulfate
7. distillationthe solvent is distilled off under reduced pressure