Hydrazine hydrate (1:1) → HCID 21187775, compound

HRID 1110010Notes

Reaction equation

HRID 1110010 reaction equation
[CH:1]([S:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][N:23]2C(=O)C3=CC=CC=C3C2=O)[CH2:17][CH2:16]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN>>[NH2:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][CH:15]([S:14][CH:1]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 211877862-[2-(4-Benzhydrylsulfanyl-piperidin-1-yl)-ethyl]-isoindole-1,3-dione

Product 1

HCID 21187775HCID 21187775, compound

Procedure

The above phthalimide was treated with hydrazine hydrate in the same manner as in Reference Example 4, to obtain the title compound, i.e. 1-(2-aminoethyl)-4-benzhydrylthiopiperidine at a yield of 92%.

Sources & evidence

ORD record
ord-030cff22a2364d6293579641a61dfce0
Source dataset
uspto-grants-1994_06
Patent number
US05324728

Reaction notes

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