HCID 3803, compound → HCID 15022009, compound

HRID 1110075Notes

Reaction equation

HRID 1110075 reaction equation
[NH2:1][C:2]1[CH:12]=[C:11]2[C:5]([C:6]([Cl:15])=[C:7]([O:13][CH3:14])[O:8][C:9]2=[O:10])=[CH:4][CH:3]=1.[C:16]1([N:22]=[C:23]=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(Cl)Cl>[C:16]1([NH:22][C:23]([NH:1][C:2]2[CH:12]=[C:11]3[C:5]([C:6]([Cl:15])=[C:7]([O:13][CH3:14])[O:8][C:9]3=[O:10])=[CH:4][CH:3]=2)=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 3803HCID 3803, compoundHCID 7672Phenyl isocyanate

Product 1

HCID 15022009HCID 15022009, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared by reaction of 110 mg (0.5 mmol) of 7-amino-4-chloro-3-methoxyisocoumarin with 60 mg (0.5 mmol) of phenyl isocyanate at room temperature in CH2Cl2 for 24 h. After standard work-up, this isocoumarin was obtained as yellow crystals; mp 203°-204° C.; MS, m/e 344 (M+). Anal. Calc. for C17H13ClN2O4 : C, 59.23; H, 3.08; N, 8.13; Cl, 10.28. Found: C, 59.28; H, 3.82; N, 8.11; Cl, 10.35.

Sources & evidence

ORD record
ord-9183b387b1004926af350618d6e40c4c
Source dataset
uspto-grants-1994_06
Patent number
US05324648

Reaction notes

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