2,3-Dihydrofuran → HCID 19019067, compound

Participants

Reaction Conditions

Reaction Steps

To 38.1 g (0.28 mol) of 3,4-dihydroxystyrene and 118 g (1.68 mol) of 2,3-dihydrofuran are added 5 drops of concentrated hydrochloric acid, whereupon an exothermic reaction ensues. The solution is stirred for 4 h at 50° C. and then poured on to a mixture of ice-water and diethyl ether. After two extractions with diethyl ether, the organic phase is washed three times at 0° C. with 1N NaOH and dried over Na2SO4. The solvent is removed by evaporation to leave a clear liquid which is purified by distillation in a bulb tube (155° C./0.02 torr) or by column chromatography (silica gel, hexane/ethyl acetate 4:1).

Provenance & Evidence