Hydrochloric Acid → 4-(3-Oxo-2-phenyl-heptyl)-benzoic acid

HRID 1110125Notes

Reaction equation

HRID 1110125 reaction equation
[O:1]=[C:2]([CH2:19][CH2:20][CH2:21][CH3:22])[CH:3]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#N)=[CH:7][CH:6]=1.[OH-:23].[Na+].C(O)C.Cl.[OH2:29]>>[O:1]=[C:2]([CH2:19][CH2:20][CH2:21][CH3:22])[CH:3]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]([OH:29])=[O:23])=[CH:7][CH:6]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 189990744-(3-Oxo-2-phenylheptyl)-benzonitrile

Product 1

HCID 189990814-(3-Oxo-2-phenyl-heptyl)-benzoic acid

Procedure

3.5 g of product of Step A with 20 ml of N sodium hydroxide solution and 50 ml of ethanol were stirred for 15 hours at reflux and the reaction medium was poured into ice-cooled water and acidified with concentrated hydrochloric acid. After separating, the residue was washed with water and dried. The crude product was impasted in 100 ml of isopropyl ether to obtain 3.27 g of the desired compound melting at 140° C.

Workup

  1. temperatureat reflux
  2. additionthe reaction medium was poured into ice-
  3. customAfter separating
  4. washthe residue was washed with water
  5. customdried

Sources & evidence

ORD record
ord-371d3c3a56d141b9a273da8f93187cf0
Source dataset
uspto-grants-1994_06
Patent number
US05324839

Reaction notes

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