反应详情

A mixture of 8.9 g of 3-(octadecyloxy)-5-[(5-methoxy-5-oxopentyl)oxy]phenylcarbamic acid phenylmethyl ester and 1.5 g of 10% palladium on carbon in 250 ml of THF was stirred in a hydrogen atmosphere at room temperature for 2.5 hours. The catalyst was removed by filtration and the filtrate was concentrated at reduced pressure to a solid which was triturated with hexane and filtered to give 6.8 g (97% yield, mp 57°-59°) of 5-[3-amino-5(octadecyloxy)phenoxy]pentanoic acid methyl ester.

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated at reduced pressure to a solid which
3. customwas triturated with hexane
4. filtrationfiltered