反应详情

A solution of 41.4 g (0.12 mol) of 3,5-bis(phenylmethoxy)benzoic acid methyl ester and 59 ml (0.36 mol) of 6N NaOH in 700 ml of methanol and 350 ml of dioxane was stirred at reflux for 17 hours. The solvents were removed at reduced pressure and the residue was dissolved in water and acidified to pH 3 with 6N HCl. The resultant solid was filtered and recrystallized from methylene chloride-methanol to give 38.6 g (97% yield, mp 211°-213°) of 3,5-bis(phenylmethoxy)benzoic acid.

1. temperatureat reflux for 17 hours
2. customThe solvents were removed at reduced pressure
3. dissolutionthe residue was dissolved in water
4. filtrationThe resultant solid was filtered
5. customrecrystallized from methylene chloride-methanol