HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3,5-Bis(phenylmethoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3,5-bis(benzyloxy)benzoate | HCID 2733652 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3,5-Bis(phenylmethoxy)benzoic acid | HCID 99307 | 97% |
Reaction Steps
A solution of 41.4 g (0.12 mol) of 3,5-bis(phenylmethoxy)benzoic acid methyl ester and 59 ml (0.36 mol) of 6N NaOH in 700 ml of methanol and 350 ml of dioxane was stirred at reflux for 17 hours. The solvents were removed at reduced pressure and the residue was dissolved in water and acidified to pH 3 with 6N HCl. The resultant solid was filtered and recrystallized from methylene chloride-methanol to give 38.6 g (97% yield, mp 211°-213°) of 3,5-bis(phenylmethoxy)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05324747 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-7bf8f9f04f154f298691aeae290231fa |
| Source note | uspto-grants-1994_06 |