反应详情

A stirred solution of 113.5 grams (0.41 mole) of 3-chloro-1-cyclopropyl-1-(4-trifluoromethoxyphenyl)-1-propene and 113.0 grams (0.43 mole) of triphenylphosphine in 400 mL of toluene was heated at reflux for 4 hours. After this time the reaction mixture was cooled and concentrated under reduced pressure to a residue. The residue was triturated with 1000 mL of diethyl ether. The ether was decanted from the residue, and the residue was triturated with two more 1000 mL portions of diethyl ether in the manner described above. The solid residue was dried under reduced pressure yielding 176.0 grams of [3-cyclopropyl-3-(4-trifluoromethoxyphenyl)-2-propen-1-yl]triphenylphosphonium chloride.

1. temperatureat reflux for 4 hours
2. temperatureAfter this time the reaction mixture was cooled
3. concentrationconcentrated under reduced pressure to a residue
4. customThe residue was triturated with 1000 mL of diethyl ether
5. customThe ether was decanted from the residue
6. customthe residue was triturated with two more 1000 mL portions of diethyl ether in the manner
7. customThe solid residue was dried under reduced pressure