Hydrochloric Acid → HCID 86744373, compound

HRID 1110443Notes

Reaction equation

HRID 1110443 reaction equation
C([NH:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:11]=2)[CH2:6]1)(=O)C.[ClH:20]>>[ClH:20].[NH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:11]=2)[CH2:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15078416HCID 15078416, compound

Product 1

HCID 86744373HCID 86744373, compoundYield 91%

Procedure

To 0.735 g of methyl (2-acetylaminoindan-5-yl)oxyacetate are added 6 ml of aqueous 10% hydrochloric acid solution, and the mixture is refluxed under stirring for 13 hours. The reaction mixture is evaporated to remove solvent and 10 ml of methanol are added to the residue. The mixture is refluxed for 1.5 hours and evaporated to remove methanol. The residue is recrystallized from methanol-diethyl ether to give 0.655 g of methyl (2-aminoindan-5-yl)oxyacetate hydrochloride as yellow prisms. Yield: 91%

Workup

  1. temperaturethe mixture is refluxed
  2. customThe reaction mixture is evaporated
  3. customto remove solvent and 10 ml of methanol
  4. additionare added to the residue
  5. temperatureThe mixture is refluxed for 1.5 hours
  6. customevaporated
  7. customto remove methanol
  8. customThe residue is recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-d6ff12c8f2b5447faf5ca205ddde5e7a
Source dataset
uspto-grants-1990_12
Patent number
US04975460

Reaction notes

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