反应详情

As in Example 134, a solution of (E)-5.5-bis(4-methoxyphenyl) -2,4-pentadienoic acid 4-nitrophenyl ester (1.72 g) and 2-Pyridinepentanamine (0.657 g) in tetrahydrofuran (25 mL) was stirred for 17 hours at room temperature and was worked up in the usual manner. The crude product was purified by HPLC (ethyl acetate) and then was crystallized from ethyl acetate to provide 4.6 g of (E)-5,5-bis(4-methoxyphenyl)-N-[5-(2-Pyridinyl) pentyl]-2,4-pentadienamide, mp 99°-100° C.

1. customThe crude product was purified by HPLC (ethyl acetate)
2. customwas crystallized from ethyl acetate