Bromoacetic Acid → 4-(4-Chlorophenoxy)-phenoxy-acetyl chloride

HRID 1110658Notes

Reaction equation

HRID 1110658 reaction equation
BrCC(O)=O.BrC(CC)C(O)=O.BrC(CCC)C(O)=O.[Cl:21][C:22]1[CH:40]=[CH:39][C:25]([O:26][C:27]2[CH:38]=[CH:37][C:30]([O:31][CH:32](C)[C:33]([Cl:35])=[O:34])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([O:26][C:27]2[CH:38]=[CH:37][C:30]([O:31][CH2:32][C:33]([Cl:35])=[O:34])=[CH:29][CH:28]=2)=[CH:39][CH:40]=1

Participants

5

Reactant 4

HCID 6227Bromoacetic AcidHCID 66552-Bromobutanoic acidHCID 11446Pentanoic acid, 2-bromo-HCID 129528252-(4-(4-Chlorophenoxy)phenoxy)propionic acid chloride

Product 1

HCID 213180704-(4-Chlorophenoxy)-phenoxy-acetyl chloride

Procedure

2-bromoacetic acid, (b) 2-bromobutyric acid, and (c) 2-bromovaleric acid in the above (A), were used to obtain (a'), 4-(4-chlorophenoxy)phenoxyacetic acid chloride, (b') 2-(4-(4-chlorophenoxy)phenoxybutyric acid chloride, (c') 2-(4-(4-chlorophenoxy)phenoxy)valeric acid chloride, respectively. Also, by using (d) 4-bromonitrobenzene instead of 4-bromochlorobenzene in the above (a), (d') 2-(4-(4-nitrophenoxy)phenoxy)propionic acid chloride was obtained.

Sources & evidence

ORD record
ord-f26425c1123a4ab284e4b8c3ba01f4a4
Source dataset
uspto-grants-1990_12
Patent number
US04976773

Reaction notes

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