2-Chloro-5-(trifluoromethyl)pyridine → 4-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)phenoxypropionic acid chloride hydrochloride

HRID 1110661Notes

Reaction equation

HRID 1110661 reaction equation
[Cl:1]C1C=CC(C(F)(F)F)=CN=1.[ClH:12].[F:13][C:14]([F:35])([F:34])[C:15]1[CH:16]=[CH:17][C:18]([O:21][C:22]2[CH:33]=[CH:32][C:25]([O:26][CH:27]([CH3:31])[C:28]([Cl:30])=[O:29])=[CH:24][CH:23]=2)=[N:19][CH:20]=1>BrC(CC)C(O)=O>[ClH:1].[Cl:12][C:17]1[C:18]([O:21][C:22]2[CH:33]=[CH:32][C:25]([O:26][CH:27]([CH3:31])[C:28]([Cl:30])=[O:29])=[CH:24][CH:23]=2)=[N:19][CH:20]=[C:15]([C:14]([F:34])([F:35])[F:13])[CH:16]=1

Participants

4

Reactant 2

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 884514002-(4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy)propionic acid chloride hydrochloride

Product 1

HCID 884514024-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)phenoxypropionic acid chloride hydrochloride

Reagents, catalysts & solvents 1

HCID 66552-Bromobutanoic acidSolvent

Procedure

By using 2-chloro-5-trifluoromethylpyridine instead of 2,3-dichloro-5-trifluoromethylpyridine in the above (b), 2-(4-(5-trifluoromethyl-2-pyridyloxy)phenoxy)propionic acid chloride hydrochloride was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-91e77a33e58d41a2b34224f9a3bb40a5
Source dataset
uspto-grants-1990_12
Patent number
US04976773

Reaction notes

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